Research News Coverage
Strained heterocyclic allenes represent a class of valuable intermediates that remain underdeveloped. Check out our synthesis of 3,4-oxacyclohexadiene precursors and studies on their utility in trapping reactions and enantiospecific Diels–Alder reactions published in ACIE.
“Collaboration” is not the first word most associate with the field of total synthesis. Yet the complexity of natural products lends itself to advancements not only in synthetic chemistry, but in biocatalysis, biosynthesis, computational chemistry, and drug discovery as well. Here we highlight recent advances in these fields brought on by collaborations in the total synthesis of natural products.
An electron-rich benzylic secondary alcohol enables the reduction of a wide range of aromatic ketones under mildly basic conditions without the need for a transition or main group metal catalysts, with the potential for synthesis of enantioenriched products!
Utilizing Ni/NHC–paraffin capsules developed by our laboratory and commercialized by TCI, undergraduates can now perform air/moisture-sensitive cross-couplings of amides in laboratory classes!
Our collaboration with Codexis has been published in Nature’s new open access chemistry journal, Communications Chemistry. Check out our chemoenzymatic approach to enantioselective alcohol synthesis from amides using C–N bond activation!
Rapid access to diverse heterocyclic conjugated scaffolds via strained intermediates. Synthetic applications include donor–acceptor fluorophores as well as conjugated fluorescent oligomers!
Check out our 100th publication! A collaboration involving nearly 100 co-authors, led by the NIH NCATS. It features 2(S)-cathafoline, a natural product our lab has synthesized.